Oncology Drug Database

Comprehensive Information on Cancer Treatment Medications

Understanding Cancer Treatment Drugs

Cancer treatment has evolved dramatically over the past decades, with new drugs offering more targeted and effective approaches. Our comprehensive drug monographs explain how each medication works, what to expect during treatment, how to manage side effects, and important safety information.

Each drug guide includes mechanism of action, dosing schedules, side effect profiles, drug interactions, monitoring requirements, and answers to frequently asked questions. All information is evidence-based and regularly updated.

Immunotherapy

Drugs that harness the immune system to fight cancer

Pembrolizumab

Brand name: Keytruda
PD-1 Inhibitor

Checkpoint inhibitor for melanoma, lung cancer, and many other tumor types. Blocks PD-1 to unleash immune response.

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Nivolumab

Brand name: Opdivo
PD-1 Inhibitor

Anti-PD-1 antibody for melanoma, lung, kidney, and other cancers. Similar mechanism to pembrolizumab with different approvals.

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Targeted Therapy

Drugs that target specific proteins or pathways in cancer cells

Bevacizumab

Brand name: Avastin
Anti-VEGF (Anti-Angiogenic)

Blocks blood vessel formation to starve tumors. Used for colorectal, lung, brain, kidney, and other cancers.

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Rituximab

Brand name: Rituxan
Anti-CD20 Antibody

Targets CD20 on B-cells for lymphoma and leukemia. Revolutionized lymphoma treatment with R-CHOP regimen.

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Chemotherapy - Platinum Agents

Platinum-based drugs that damage DNA to kill cancer cells

Cisplatin

Brand name: Platinol
Platinum Agent

Cornerstone of many regimens for testicular, lung, bladder, and other cancers. Requires aggressive hydration.

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Carboplatin

Brand name: Paraplatin
Platinum Agent

Similar to cisplatin but less kidney toxic. Used for ovarian, lung, and other cancers.

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Oxaliplatin

Brand name: Eloxatin
Platinum Agent

Part of FOLFOX regimen for colorectal cancer. Unique cold-induced peripheral neuropathy side effect.

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Chemotherapy - Taxanes

Microtubule inhibitors that prevent cell division

Paclitaxel

Brand name: Taxol
Taxane

Widely used for breast, ovarian, and lung cancers. Stabilizes microtubules to block cell division.

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Docetaxel

Brand name: Taxotere
Taxane

More potent than paclitaxel. Used for breast, lung, prostate, and gastric cancers. Requires steroid premedication.

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Chemotherapy - Antimetabolites

Drugs that interfere with DNA/RNA synthesis

5-Fluorouracil (5-FU)

Brand name: Adrucil
Antimetabolite

Backbone of many regimens for colorectal and GI cancers. Usually given as continuous IV infusion.

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Capecitabine

Brand name: Xeloda
Antimetabolite (Oral Prodrug)

Oral chemotherapy that converts to 5-FU in the body. Key side effect: hand-foot syndrome.

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Gemcitabine

Brand name: Gemzar
Antimetabolite

Standard for pancreatic cancer. Also used for lung, bladder, and ovarian cancers.

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Chemotherapy - Topoisomerase Inhibitors

Drugs that interfere with DNA replication enzymes

Irinotecan

Brand name: Camptosar
Topoisomerase I Inhibitor

Part of FOLFIRI for colorectal cancer and FOLFIRINOX for pancreatic cancer. Two types of diarrhea require different management.

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Chemotherapy - Anthracyclines

Potent drugs that intercalate DNA and generate free radicals

Doxorubicin

Brand name: Adriamycin
Anthracycline

One of the most effective chemotherapy drugs. Used for breast cancer, lymphoma, sarcoma. Monitor for heart toxicity.

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Chemotherapy - Alkylating Agents

Drugs that directly damage DNA through alkylation

Temozolomide

Brand name: Temodar
Alkylating Agent

Oral chemotherapy for glioblastoma and brain tumors. Crosses blood-brain barrier. MGMT methylation predicts response.

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Drug Database Statistics

17 drugs currently in database with comprehensive monographs

6 drug classes represented: immunotherapy, targeted therapy, platinum agents, taxanes, antimetabolites, and more

Regularly updated with latest FDA approvals, clinical trial data, and treatment guidelines